Caffeine: the world’s favorite molecule

Caffeine (1,3,7-trimethylxanthine) is a naturally occurring central nervous system stimulant belonging to the methylxanthine class.  Methylxanthine is a group of chemical compounds containing one or more methyl (CH3) groups on a xanthine molecule or a purine base. It is naturally occurring in approximately 60 plants including coffee beans, many types of tea, and cacao beans. …

Journavx: The New Pain Kid on the Block

The FDA just approved Journavx for treatment in moderate-to-severe acute pain in adults.  It is the first-in-class non-opioid pain medication.  Journavx targets the pain-signaling pathway, specifically the sodium channel NaV1.8, in the peripheral nervous system before pain signals reach the brain.  Since NaV1.8 is not expressed in the central nervous system, it is not expected…